BOARD OF DIRECTORS

    David Mott
    Chairman of the Board
    General Partner, New Enterprise Associates, Inc.

    David M. Mott joined NEA in September 2008 as a General Partner focused on biopharmaceutical investments. Prior to joining NEA, he was President and Chief Executive Officer of MedImmune, subsidiary of AstraZeneca Plc, and Executive Vice President of AstraZeneca. Dave joined MedImmune in 1992 and served in roles of increasing responsibility including Chief Operating Officer, Chief Financial Officer, President and Chief Executive Officer as the company grew from a venture-backed startup (founded in 1988) into one of the top five biotechnology companies in the world. Ultimately, he initiated and executed the sale of MedImmune to AstraZeneca in June 2007 for $15.6 billion. In 2002, Dave founded MedImmune Ventures and chaired its investment committee through his departure from MedImmune. At the time of his departure in July 2008, MedImmune had annual revenues in excess of $1.5 billion, annual R&D in excess of $650 million and approximately 3,000 employees. Prior to joining MedImmune, Dave was a Vice President in the Health Care Investment Banking Group at Smith Barney, Harris Upham & Co. Inc. At Smith Barney, his activities included public and private equity and debt financings as well as merger and acquisition work for biotechnology, healthcare services, and medical product and device companies.

    Dave is currently Chairman of 3-V Biosciences and Zyngenia, and is a director of Ardelyx, Epizyme, TESARO, and Zosano Pharma. He serves on the Advisory Board of the Scripps Translational Science Institute and the Governing Board of St. Albans School.

    Robert Garland, MD
    Partner, New Enterprise Associates, Inc.

    Dr. Garland joined NEA in 2003 and invests in biopharmaceuticals and medical devices. He is a director of 3-V Biosciences, Cardioxyl Pharmaceuticals, Trevena, Inc., and Zyngenia, Inc. Prior to NEA, in addition to clinical practice at the University of California, San Francisco (UCSF), he was with McKinsey & Company’s Pharmaceutical & Medical Products and Corporate Finance & Strategy practices. At McKinsey, Dr. Garland worked with biotech, pharmaceutical, medical device, diagnostics, and private equity clients to evaluate investments, formulate product and corporate strategies and build businesses. Dr. Garland completed his Residency in Internal Medicine and Fellowship in Infectious Diseases at UCSF and received his MBA and MPH from the University of California, Berkeley, his MD from Baylor College of Medicine, and his BS in EE/Bioengineering from Rice University.

    Ari Helenius, PhD
    – Professor for Biochemistry, Institute of Biochemistry, ETH Zürich
    – World leader studying over 20 virus-host cell interactions
    – Member of U.S. National Academy of Sciences
    – Awarded the Benoist Prize in 2007

    One of the Founders of 3-V and full Professor of Biochemistry at the Institute of Biochemistry, ETH Zurich since November 1997. He currently heads several interdisciplinary projects in the fields of protein folding and
    virus-host cell interactions. His research focuses on membrane biology, virology and protein chemistry. Prof. Helenius’ group is currently working on two fundamental questions:

    1. By which mechanism are viruses able to enter host cells and how do they reach the nucleus where they multiply?
    2. How are newly synthesized proteins folded within the organelles of the living cell, and how does the cellular quality control system work, deciding whether proteins in the endoplasmic reticulum are correctly folded or not?

    Prof. Helenius was previously chairman of the Department of Cell Biology at Yale University, New Haven, CT (1992-97), having been a full professor there since 1983. Prior to joining Yale, Prof. Helenius was a staff scientist at the European Laboratory for Molecular Biology (EMBL) in Heidelberg. Prof. Helenius studied biochemistry at the University of Helsinki and received his doctorate under Professor Kai Simons and was awarded the Komppa Prize for the best dissertation on chemistry in Finland in 1973.

    Gordon Ringold, PhD
    Chairman and CEO, Alavita Pharmaceuticals, Inc.
    Director for Silicon Valley Initiatives, UC Santa Cruz

    Dr. Ringold is currently Director for Silicon Valley Initiatives, UC Santa Cruz and Executive Chairman of Alavita Pharmaceuticals. Ringold is a co-founder and Director of Maxygen and Alexza Corporations and Managing Partner of Technogen Associates, L.P., a private investment firm; he has over twenty-five years experience managing the discovery and development of pharmaceuticals and novel, enabling life science technologies. From 1997 to 2005, Dr. Ringold served as Chairman and CEO of SurroMed, Inc., a biotechnology company focused on biomarker discovery technologies. From 1995 to 2000, Dr. Ringold was CEO of the Glaxo-Wellcome Group’s Affymax Research Institute, where he managed the development of novel technologies to accelerate the pace of drug discovery. Before serving as CEO, Dr. Ringold was the President and Scientific Director of Affymax where he was instrumental in nurturing the development of the DNA shuffling technology and interacting with key parties to establish Maxygen. Prior to Affymax, he served as Director and Vice President of the Institute for Cancer and Development Biology at Syntex, now a division of Hoffman La-Roche.

    Dr. Ringold received his BA and BS in Biology from University of California, Santa Cruz, and his PhD in Microbiology from University of California, San Francisco in the laboratory of Dr. Harold Varmus. He was on the faculty of the Department of Pharmacology at the Stanford University School of Medicine from 1978-1987.

    Beth Seidenberg, MD
    Partner, Kleiner Perkins Caulfield & Byers

    Dr. Seidenberg joined Kleiner Perkins Caufield & Byers (KPCB) in May 2005 to work in the life sciences area. For the past 20 years, she has focused her career on introducing new innovative treatments for AIDS, arthritis, asthma, cancer, psoriasis, cardiovascular, metabolic, neurological and renal disorders. She introduced 10 innovative products to market and achieved over 40 regulatory approvals (including new indications and formulations) on a worldwide basis. These products have been successfully commercialized and have provided benefits to millions of patients with grievous illnesses and have generated several billion dollars of revenue.

    Prior to joining KPCB, Dr. Seidenberg was Senior Vice President, Global Development, and Chief Medical Officer at Amgen, Inc., the world’s largest biotechnology company. During her three years there, Dr. Seidenberg’s responsibilities included all stages of clinical research, regulatory affairs, safety, health economics/ reimbursement and medical affairs. Prior to joining Amgen, Dr. Seidenberg was a senior executive in research and development at Bristol-Myers Squibb Company and Merck & Co., Inc. She began her career in basic and clinical research at the National Institutes of Health specializing in immunology and infectious diseases.

    Dr. Seidenberg received her BS from Barnard College magna cum laude, Phi Beta Kappa; and her medical degree from the University of Miami School of Medicine, alpha omega alpha. Her post-graduate training was completed at Johns Hopkins, George Washington School of Medicine and the National Institutes of Health.

    James F. Young, PhD
    In addition to his Board seat with 3-V, Dr. Young currently serves on the Board of Directors of Novavax, Inc. and on the Board of Trustees of The Phillips Collection Museum of Modern Art in Washington, D.C., and recently graduated first in his class with a Certificate de Cuisine from Le Cordon Bleu Academie d’Art Culinaire de Paris in Paris, France. Previously, Dr. Young was with MedImmune, Inc. from 1988 through 2008 following its sale to AstraZeneca PLC. During his entire tenure, Dr. Young led MedImmune’s research and development organization and was directly involved in the development of approximately twenty clinical programs and commercialization of Synagis9® , RespiGam®, CytoGam®, Flumist®, and Ethyol®. At the time of his retirement from MedImmune, Dr. Young oversaw R&D functions including approximately 1,500 people and an annual budget in excess of $600 million. Prior to MedImmune, Dr. Young was a Director in the Department of Molecular Genetics at Smith Kline and French Laboratories. Dr. Young has served on the Boards of Directors of Xencor, Inc., Iomai, Inc. and Arriva Pharmaceuticals, Inc. He received his Ph.D. in Microbiology and Immunology from Baylor College of Medicine.

    Merdad Parsey, MD, PhD
    CEO

    Dr. Parsey joined 3-V Biosciences as its President and Chief Executive Officer in September 2010. Prior to joining 3-V, Dr. Parsey held positions of increasing responsibility at Genentech, Inc., a member of the Roche Group, most recently as Senior Group Medical Director in Genentech Research and Early Development, overseeing early clinical development in multiple therapeutic areas. Prior to his tenure with Genentech, Dr. Parsey was with Sepracor, Regeneron and Merck, Inc. He has worked on multiple development and post-marketing programs from initial human trials to NDA/BLA submissions in Respiratory, Inflammation, Virology, Neurology, Opthalmology and Gastrointestinal diseases. In addition to his work in the biotechnology and pharmaceutical industries, Dr. Parsey was the Director of Critical Care Medicine at the NYU School of Medicine. He completed his MD and PhD at the University of Maryland, his residency in Internal Medicine at Stanford University and his fellowship in Pulmonary and Critical Care Medicine at the University of Colorado.

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